Address
Department of Bioengineering
and
Associated Laboratory – Institute for Biotechnology and Bioengineering
Instituto Superior Técnico
Universidade Técnica de Lisboa
Avenida Rovisco Pais
1049-001 Lisboa - Portugal
Tel: +351.21.8419063
Fax: +351.21.8419062
E-mail: joaquim.cabral@ist.utl.pt
URL: http://www.researcherid.com/rid/G-2052-2010
Academic Positions
Professor of Bioengineering, Instituto Superior Técnico (1992-present)
Associate Professor, Instituto Superior Técnico (1987-1991)
Assistant Professor, Instituto Superior Técnico (1983-1986)
Academic Background
Diploma in Chemical Engineering, Instituto Superior Técnico, Technical University of Lisbon (1976)
Ph.D., Instituto Superior Técnico, Technical University of Lisbon, (1983)
Post-Doctoral Fellow, Massachusetts Institute of Technology, U.S.A. (1983-84)
D.Sc., Instituto Superior Técnico, Technical University of Lisbon, (1989)
Membership and Scientific Positions
- Director, Associated Laboratory – Institute for Biotechnology and Bioengineering (2006 – present)
- Founder and Head of Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon (2011 – present)
- Head of Department of Chemical and Biological Engineering, Instituto Superior Técnico, Technical University of Lisbon (2002-2009)
- Head of the BioEngineering Research Group of Instituto Superior Técnico, Technical University of Lisbon (1990-present)
- Director of the Doctoral Programme on Bioengineering, IST (collaboration with MIT) (2007 – present)
- Co-Coordinator of MIT-Portugal Program – Bioengineering Systems Focus Area (2006 – present)
- Member of the Working Party/Section on Applied Biocatalysis of European Federation of Biotechnology (1986-present) (Chairman 1991-1996)
- Honorary Member of the Section on Applied Biocatalysis of European Federation of Biotechnology (2005)
- Member and Chairman of the Task Group on Biotransformation of the European Federation of Biotechnology Section on Biochemical Engineering Science (1996-2004)
- Member of the Executive Committee of Process Integration in Biochemical Engineering Programme of European Science Foundation (1992-1997)
- Member of the Executive Committee of the European Biochemical Engineering Network (1993-1996)
- Member of the Executive Committee of the EFB Section on European Biochemical Engineering Science (1999, 2001, 2002-2004)
Advisory Boards and Peer-Review Activities
- President of the Exact Sciences and Engineering Scientific Council of the Portuguese Foundation for Science and Technology (2009-present)
- Member of the Biotechnology Strategy Group of the European Academies’ Science Advisory Council (EASAC) – Executive Secretary, The Royal Society (2002-2005)
- Member of the Biotechnology and Biological Sciences Research Council Review Committee of “The Advanced Centre for Biochemical Engineering” “University College London”, March 1995, September 1997, January 2005
- Member of the Engineering and Physical Sciences Research Council Review Committee of “The Advanced Centre for Biochemical Engineering” “University College London”, January 2005
- Member of the Expert Panel of the Engineering and Physical Sciences Research Council, UK (2006 – 2009)
- Member of the International Peer Review Committee of the B-Basic Programme, Advanced Chemical Technologies for Sustainability, NWO, The Netherlands, September 2004, October 2005, May 2007
- Member of the Peer Review Committee of the “Biotechnology Delft-Leiden - Graduate Research School”, December 1998
- Coordinator of the Research Coordination Committee of the Portuguese Biotechnology Programme (1995-1997)
- Member of the Peer Review Committee for Research Grants of the Portuguese Biochemical Engineering and Biotechnology area (since 1990)
Editorships and Editorial Boards of Scientific Journals
- Associate Editor of Biotechnology and Applied Biochemistry (2002-present)
- Associate Editor of Biocatalysis and Biotransformation (2001-2003)
- Review Editor of Biocatalysis and Biotransformation (2004 – 2007)
- Section Editor BMC Biotechnology, Cellular and Tissue Engineering (2011 – present)
- Member of the Editorial Board of:
- Biocatalysis and Biotransformation, - Bioprocess and Biosystems Engineering, - Biotechnology Letters, - BMC Biotechnology, - Catalysis Communications, - Current Tissue Engineering, - Electronic Journal of Biotechnology, - Enzyme Research, - Journal of Biotechnology, - Journal of Chemical Technology and Biotechnology, - Journal of Regenerative Medicine and Tissue Engineering, - Journal of Tissue Engineering and Regenerative Medicine, - Trends in Biotechnology
Research interests
My current research and future vision aims at contributing for the development of biochemical engineering science through novel developments in Enzyme Engineering, Bioprocess Engineering and Stem Cell Bioengineering.
Publications
Books – 6; Review Articles – 43; Refereed Articles - 405
Selected Publications:
Books
JMS Cabral, L Boross, D Best, J Tramper (eds.) "Applied Biocatalysis", Harwood Academic Press, Reading, 1994, pp. 1 – 474
JMS Cabral, M Mota, J Tramper (eds.) “Multiphase Bioreactors Design”, Taylor & Francis Books Ltd, United Kingdom, 2001, pp. 1-493
JMS Cabral “Cell Partitioning in Aqueous Two-Phase Polymer Systems” in Cell Separation: Fundamentals, Analytical and Preparative Methods Series: Advances in Biochemical Engineering/Biotechnology, Vol. 106 (Kumar, Ashok; Galaev, Igor Yu; Mattiasson, Bo Eds.), 2007, pp. 151 -171
Recent Representative Articles (Stem Cells for Regenerative Medicine and Tissue Engineering)
- Santhagunam A, Madeira C, Cabral JMS “Genetically engineered stem cell-based strategies for articular cartilage regeneration” Biotechnol. Appl Biochem 59, 121-131 (2012)
- Andrade PZ, da Silva CL, dos Santos F, Almeida-Porada G, Cabral JMS “Initial CD34(+) Cell-Enrichment of Cord Blood Determines Hematopoietic Stem/Progenitor Cell Yield Upon Ex Vivo Expansion” J. Cell Biochem., 112, 1822-1831 (2011)
- dos Santos, F; Andrade, PZ; Abecasis, MM; Gimble, JM; Chase, LG; Campbell, AM; Boucher, S; Vemuri, MC; da Silva, CL, Cabral, JMS “Toward a Clinical-Grade Expansion of Mesenchymal Stem Cells from Human Sources: A Microcarrier-Based Culture System Under Xeno-Free Conditions” Tissue Eng.: Part C, 17, 1201-1210 (2011)
- Fernandes-Platzgummer A; Diogo MM.; Baptista RP., da Silva, CL, Cabral, JMS “Scale-Up of Mouse Embryonic Stem Cell Expansion in Stirred Bioreactors” Biotechnol. Prog. 27, 1421-1432 (2011)
- Rodrigues CAV, Fernandes TG, Diogo MM, da Silva CL, Cabral JMS “Stem cell cultivation in bioreactors” Biotechnol. Adv 29, 815-829 (2011)
- Madeira C, Ribeiro SC, Pinheiro ISM, Martins SAM, Andrade PZ, da Silva CL, Cabral JMS “Gene delivery to human bone marrow mesenchymal stem cells by microporation” J. Biotechnol., 151, 130-136 (2011)
- Rodrigues CAV, Diogo MM, da Silva CL, Cabral JMS “Microcarrier expansion of mouse embryonic stem cell-derived neural stem cells in stirred bioreactors” Biotechnol. Appl. Biochem. 58, 231-242 (2011)
- Andrade, P.Z., dos Santos, F., Almeida-Porada, G., da Silva, C.L., Cabral, J.M.S., “Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells”, Mol. BioSyst., 6, 1207-1215 (2010)
- Fernandes, T.G., Diogo, M.M., Fernandes-Platzgummer, A., da Silva, C.L., Cabral, J.M.S., “Different stages of pluripotency determine distinct patterns of proliferation, metabolism and lineage commitment of embryonic stem cells under hypoxia”, Stem Cell Res., 5, 76-89 (2010)
- Fernandes, T.G., Fernandes-Plaztgummer, A.M., da Silva, C.L., Diogo, M.M., Cabral, J.M.S., “Kinetic and metabolic analysis of mouse embryonic stem cell expansion under serum-free conditions”, Biotechnol. Letters, 32, 171-179 (2010)
- Madeira, C., Mendes, R.D., Ribeiro, S.C., Boura, J.S, Aires-Barros, M.R., da Silva, C.L., Cabral, J.M.S., “Non-viral gene delivery to mesenchymal stem cells using cationic liposomes for gene and cell therapy”, J. Biomed. Biotechnol.,vol. 2010, Article ID 735349, 12 pages (2010)
- Madeira, C., Ribeiro, S., Turk, M.Z., Cabral, J.M.S., “Optimization of gene delivery to HEK293T cells by microporation using a central composite design methodology”, Biotechnol. Letters, 32, 1393-1399 (2010)
- Ribeiro, S.C., Mendes, R., Madeira, C., Monteiro, G., da Silva, C.L., Cabral, J.M.S., “A quantitative method to evaluate mesenchymal stem cell lipofection using real-time PCR”, Biotechnol. Prog., 26, 1501-1514 (2010)
- Eibes G, dos Santos F, Andrade PZ, Boura JS, Abecasis MMA, da Silva CL, Cabral JMS “Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system” J Biotechnol. 146, 194-197 (2010)
- Rodrigues CAV, Diogo MM, da Silva CL, Cabral JMS “Hypoxia Enhances Proliferation of Mouse Embryonic Stem Cell-Derived Neural Stem Cells” Biotechnol. Bioeng.106, 260-270 (2010)
- Fernandes TG, Kwon SJ, Bale SS, Lee MY, Diogo MM, Clark DS, Cabral JMS, Dordick JS “Three-Dimensional Cell Culture Microarray for High-Throughput Studies of Stem Cell Fate” Biotechnol. Bioeng. 106, 106-118 (2010)
- da Silva CL, Goncalves R, dos Santos F, Andrade PZ, Almeida-Porada G, Cabral JMS “Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34(+), CD34(+)CD38(-) and early lymphoid CD7(+) cells” J Tissue Eng Reg Med 4, 149-158 (2010)
- dos Santos F, Andrade PZ, Boura JS, Abecasis MM, da Silva CL, Cabral JMS “Ex Vivo Expansion of Human Mesenchymal Stem Cells: A More Effective Cell Proliferation Kinetics and Metabolism Under Hypoxia” J. Cellular Physiology 223, 27-35 (2010)
- Fernandes, TG, Diogo, MM, Clark, DS, Dordick, JS, Cabral, JMS, “High-Throughput Cellular Microarray Platforms: Potential Applications in Drug Discovery, Toxicology, and Stem Cell Research” Trends Biotechnology 27 (6), 342-349 (2009)
- da Silva, CL, Gonçalves, R, Porada, CD, Ascenção, JL, Zanjani, ED, Cabral, JMS, Almeida Porada, G “Differences amid bone marrow and cord blood hematopoietic stem/progenitor cell division kinetics J. Cellular Physiology 220, 102-111 (2009)
- Diogo, MM, Henrique, D, Cabral, JMS “Optimization and integration of expansion and neural commitment of mouse embryonic stem cells” Biotechnol Appl Biochem. 49, 105-112 (2008)
- Fernandes, TG, Kwon, SJ, Lee, MY, Clark, DS, Cabral, JMS, Dordick, JS, “An On-Chip, Cell-Based Microarray Immunofluorescence Assay for High-Throughput Analysis of Target Proteins”, Anal. Chem. 80, 6633-6639 (2008)
- Fernandes AM, Fernandes TG, Diogo MM, da Silva CL, Henrique D, Cabral JMS “Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system” J. Biotechnol. 132, 227-236 (2007)
- Abranches, E, Bekman, E, Henrique, Cabral, JMS “Expansion of Mouse Embryonic Stem Cells on Microcarriers” Biotechnol. Bioeng. 96, 1211-1221 (2007)
- Abranches, E, O'Neill, A, Robertson, MJ, Schaffer, DV, Cabral, JMS ”Development of quantitative PCR methods to analyse neural progenitor cell culture state” Biotechnol. Appl. Biochem., 44,1-8 (2006)
- Gonçalves, R, Lobato da Silva, C, Cabral, JMS, Zanjani, ED, Almeida-Porada, G “A Stro-1+ Human Universal Stromal Feeder Layer to Expand/Maintain Human Bone Marrow Hematopoietic Stem/Progenitor Cells In a Serum–Free Culture System”, Exp. Hematology, 34, 1353-1359 (2006)
- da Silva, CL, Gonçalves, R, Crapnell, KB, Cabral, JMS, Zanjani, ED, Almeida-Porada, G, “A human stromal-based serum free culture system supports the ex vivo expansion/maintenance of bone marrow and cord blood hematopoietic stem/progenitor cells”, Exp. Hematol., 33, 828–835 (2005)
