Jasem Saki, N. Mohammadpour, F. Moramezi and S. Khademvatan
Department of Medical Parasitology and Health Research Institute, Infectious and Tropical Diseases Research Center,Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Introduction: Toxoplasma gondii is protozoan parasite causing toxoplasmosis in animals and humans. The agent can pass to fetus during pregnancy via transplacental transmission. The aim of this study was to determine the relationship between Toxoplasma infection and abortion via detection of anti-Toxoplasma gondii antibodies in sera of women with obstetrical problems and compare the results with control group consisting of women with history of normal delivery.
Material and Methods: Sera from 130 women with abortion and sera of 130 women with normal delivery were collected and the IgG and IgM anti-Toxoplasma gondii antibodies were tested by ELISA method.
Result: The results showed 24.6% of the samples with abortion and 21.5% of the samples with normal delivery were positive for IgG antibodies. However, no significant differences were seen (𝑃 > 0.05). In addition, IgM antibody was detected only in one woman with abortion history but not in women with normal childbirth. The current survey revealed no significant difference between the case and control groups in IgG anti-Toxoplasma antibody but detected one sample with IgM antibodies in woman with abortion during the first trimester of pregnancy is need to more studies.
Conclusion: In order to determine the relationship between Toxoplasma infection and abortion, using methods with more specificity and sensitivity such as PCR and anti-Toxoplasma IgG avidity are recommended.
Keywords: Toxoplasma gondii, women, Abortion, Seroprevalence.