Kyung-Hyun Cho,Jae-Yong Kim and Seong-Min Kim
School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea
We investigated functional and structural changes in lipoproteins at the molecular level after consumption of policosanol. To investigate the physiological effect of policosanol, we analyzed serum parameters in young non-smoker (YN, n=7, 24.0±2.4 years old), young smoker (YS, n=7, 26.3±1.5 years old), and middle-aged subjects (MN, n=11, 52.5±9.8 years old) who consumed policosanol daily (10 mg/day) for 8 weeks. After 8 weeks, systolic blood pressure was significantly lowered to 4% (7 mmHg, p=0.022) from initial level in the YS and MN groups. Serum triglyceride (TG) level decreased to 28% and 26% from initial level in the YN and MN groups, respectively. Serum cholesteryl ester transfer protein (CETP) activity was significantly diminished up to 21% and 32% from initial level in the YN and MN groups, respectively. After 8 weeks, oxidation in the LDL fraction was remarkably reduced. In the HDL fraction, paraoxonase activity was elevated by 17% along with elevation of apolipoprotein A-I (apoA-I) and cholesterol contents. Electron microscopy revealed that size and number of HDL particles increased after 8 weeks, and the YS group showed a 2-fold increase in particle size. These functional enhancements of HDL can prevent and/or attenuate aging-related diseases, hypertension, diabetes, and coronary heart disease.
Keywords: Policosanol, HDL functionality, blood pressure, apoA-I, cholesteryl ester transfer protein.